Endocrine Abstracts

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...

Introduction: Despite the fact that CS is widely employed, further investigation on the topic of the physiology vis a vis this type of delivery is required, especially regardingstress related hormonal response during this practice. The aim of this study is to provide data regarding stress related hormonal response during Vaginal Delivery (VD) and elective CS evaluating levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1).<p...

Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...